Our Work

Research Interests

    - Function and structure of DC specific molecules
    - Identification of DC specific gene transcripts
    - Manipulation of DCs using siRNAs
    - Elucidation of the role of DC during viral infections
    - Role of DC during induction of tolerance
    - in vivio models for autoimmunity and transplantation



DC and CD83 related Publications from our Group

2007

    Kummer M., Turza N.M., Muhl-Zurbes P., Lechmann M., Boutell C., Coffin R.S., Everett R.D., Steinkasserer A. and Prechtel A.T.
    Herpes Simplex Virus Type 1 (HSV-1) Induces CD83 Degradation in Mature Dendritic Cells with Immediate Early Kinetics via the Cellular Proteasome.
    J Virol 2007.
    View Abstract - Open in PubMed


    Prechtel A.T., Turza N.M., Theodoridis A.A. and Steinkasserer A.
    CD83 Knockdown in Monocyte-Derived Dendritic Cells by Small Interfering RNA Leads to a Diminished T Cell Stimulation.
    J.Immunol. 178 (9):5454-5464, 2007.
    View Abstract - Open in PubMed


    Prechtel A.T. and Steinkasserer A.
    CD83: an update on functions and prospects of the maturation marker of dendritic cells.
    Arch.Dermatol.Res. 2007.
    View Abstract - Open in PubMed


2006

    Prechtel A.T., Turza N.M., Theodoridis A.A., Kummer M. and Steinkasserer A.
    Small interfering RNA (siRNA) delivery into monocyte-derived dendritic cells by electroporation.
    J.Immunol.Methods 311 (1-2):139-152, 2006.
    View Abstract - Open in PubMed


    Zinser E., Lechmann M., Golka A., Hock B. and Steinkasserer A.
    Determination of the inhibitory activity and biological half-live of soluble CD83: Comparison of wild type and mutant isoforms.
    Immunobiology 211 (6-8):449-453, 2006.
    View Abstract - Open in PubMed


2005

    Lechmann M., Kotzor N., Zinser E., Prechtel A.T., Sticht H. and Steinkasserer A.
    CD83 is a dimer: Comparative analysis of monomeric and dimeric isoforms.
    Biochem.Biophys.Res.Commun. 329 (1):132-139, 2005.
    View Abstract - Open in PubMed


    Prechtel A.T., Turza N.M., Kobelt D.J., Eisemann J.I., Coffin R.S., McGrath Y., Hacker C., Ju X., Zenke M. and Steinkasserer A.
    Infection of mature dendritic cells with herpes simplex virus type 1 dramatically reduces lymphoid chemokine-mediated migration.
    J Gen Virol 86 (Pt 6):1645-1657, 2005.
    View Abstract - Open in PubMed


2004

    Kotzor N., Lechmann M., Zinser E. and Steinkasserer A.
    The soluble form of CD83 dramatically changes the cytoskeleton of dendritic cells.
    Immunobiology 209 (1-2):129-140, 2004.
    View Abstract - Open in PubMed


    Zinser E., Lechmann M., Golka A., Lutz M.B. and Steinkasserer A.
    Prevention and treatment of experimental autoimmune encephalomyelitis by soluble CD83.
    J.Exp.Med. 200 (3):345-351, 2004.
    View Abstract - Open in PubMed


    Zinser E., Turza N. and Steinkasserer A.
    CNI-1493 mediated suppression of dendritic cell activation in vitro and in vivo.
    Immunobiology 209 (1-2):89-97, 2004.
    View Abstract - Open in PubMed


2003

    Kobelt D., Lechmann M. and Steinkasserer A.
    The interaction between dendritic cells and herpes simplex virus-1.
    Curr.Top.Microbiol.Immunol. 276 145-161, 2003.
    View Abstract - Open in PubMed


2002

    Lechmann M., Berchtold S., Hauber J. and Steinkasserer A.
    CD83 on dendritic cells: more than just a marker for maturation.
    Trends Immunol 23 (6):273-275, 2002.
    View Abstract - Open in PubMed


    Lechmann M., Kremmer E., Sticht H. and Steinkasserer A.
    Overexpression, purification, and biochemical characterization of the extracellular human CD83 domain and generation of monoclonal antibodies.
    Protein Expr.Purif. 24 (3):445-452, 2002.
    View Abstract - Open in PubMed


    Lechmann M., Zinser E., Golka A. and Steinkasserer A.
    Role of CD83 in the immunomodulation of dendritic cells.
    Int.Arch.Allergy Immunol. 129 (2):113-118, 2002.
    View Abstract - Open in PubMed


2001

    Jenne L., Thumann P. and Steinkasserer A.
    Interaction of large DNA viruses with dendritic cells.
    Immunobiology 204 (5):639-648, 2001.
    View Abstract - Open in PubMed


2000 and before

    Kruse M., Rosorius O., Kratzer F., Stelz G., Kuhnt C., Schuler G., Hauber J. and Steinkasserer A.
    Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T-cell stimulatory capacity.
    J.Virol. 74 (15):7127-7136, 2000.
    View Abstract - Open in PubMed


    Kruse M., Rosorius O., Kratzer F., Bevec D., Kuhnt C., Steinkasserer A., Schuler G. and Hauber J.
    Inhibition of CD83 cell surface expression during dendritic cell maturation by interference with nuclear export of CD83 mRNA.
    J.Exp.Med. 191 (9):1581-1590, 2000.
    View Abstract - Open in PubMed


    Strobel I., Berchtold S., Gotze A., Schulze U., Schuler G. and Steinkasserer A.
    Human dendritic cells transfected with either RNA or DNA encoding influenza matrix protein M1 differ in their ability to stimulate cytotoxic T lymphocytes.
    Gene Ther. 7 (23):2028-2035, 2000.
    View Abstract - Open in PubMed





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